What are the preterm labor monitoring recommendations for twin pregnancies? The concordance rate of major congenital malformations is approximately 20% in monozygotic twins. The incidence of congenital anomalies is 3-5 fold higher in monozygotic twins than in singletons or dizygotic twins thus, we stress the importance of an early anatomy ultrasound. However, understanding the higher risk of false positives and false negatives associated with the use of cell-free fetal DNA in twin pregnancies, this test can be offered to patients who are over the age of 33 or 35 (depending on the kind of twins). The use of cell-free fetal DNA in twin pregnancies is currently not supported by ACOG. Cell-free fetal DNA from the mother’s plasma is available as a screening test for singleton pregnancies at higher risk of aneuploidy.Invasive diagnostic testing with chorionic villus sampling (CVS) or amniocentesis are available options.
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